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EFFICACY
STUDIES/ SCIENTIFIC ARTICLES |
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| Taurine |
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Taurine
is unpopular but yet one of the most abundant amino acids
in the body. It is chiefly found in the central nervous system,
muscles, retina, adrenal glands and it is very concentrated
in the brain. 1
Children appear to be more
dependent on dietary taurine than adults. 5 Taurine is essential
in newborns because they are not able to synthesize it. Healthy
adults make their own taurine from other amino acids, by converting
methionine in the body and cysteine in the liver, with the
help from Vitamin B 6. However, taurine is considered to be
a “conditionally essential” amino acid in nutrition
meaning that deficiency result in a clinical consequences
which can be reversed by supplementation. 1 When under special
condition, the body may not able to produce enough taurine
for the demand. Injury, stress, diseases and even exercise
deplete taurine and the body may not able to maintain the
level in short time. |
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Taurine Essential for… |
Nervous
System. Research
indicates that taurine plays an important role in the development
of nervous system. It is speculated that taurine concentration
regulation, in conjunction with glutamate concentration regulation,
calcium fluxes, taurine-zinc interaction may present a communication
between neuron and glial cells. 3,6 Hence, t aurine can be
considered as one of the determinant nutritional molecules
during development and regeneration of the central nervous
system. 3
Brain Development.
Taurine is an important osmolyte, which play an important
role in the cell volume regulatory process in the brain. 1
On top of that, higher concentration in the developing brain
indicate that a vital function for taurine in brain development.
Clinical research showed that taurine improves attention and
memory. 4 Taurine is also an inhibitory neurotransmitter,
and its main use has been to help to treat children with epilepsy
4, cystic fibrosis as well as auditory brainstem-evoked responses
in preterm infants. 2
Retina.
Taurine is present in high concentrations in the retina of
all species. Taurine in the retina might function in the protection
of the photoreceptor and regulating signal transduction. 7
It has been established that visual dysfunction in both human
and animal subjects results from taurine deficiency. However,
the deficiency is reversed with simple nutritional supplementation
with taurine. 5
Fat Absorption.
Taurine has a vital role in fat absorption because taurine-conjugated
bile acids are better emulsifiers of fat than other glycine-conjugated
bile acids. In other words, it helps in fat-soluble vitamins
in the body. Taurine is also playing a role in receiving calorie
of infant, children and even adult (75%) from their diet.
1 On top of that, the central nervous system (brain) of the
human body is predominantly composed of lipids. Due to the
contribution of long chain polyunsaturated fatty acid in the
brain, neural and retinal tissues, shortage of this fatty
acid might alter normal brain function. 8 Thus, the efficiency
of lipid absorption is very important for children’s
brain and retina growth/development. |
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| Taurine Deficiency Causes…
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Absence from
the diet of a conditionally essential nutrient does not produce
immediate deficiency disease but in long term can cause problem.
2 However, taurine deficiency produces physical and functional
modifications in the brain and in the retina. 3 |
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| Taurine Is Found In… |
Because taurine
is a conditioning essential amino acid, therefore an RDA has
not been established. Vegetables and grains do not contain
taurine. Taurine is mostly found in meat and fish. |
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References: |
| 1. |
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Chesney, R.W., Helms, R.A., Christensen,
M., Budreau, A.M, Han, X. &
Sturman, J.A. 1998. The role of taurine in infant nutrition.
Adv Exp Med Biol 442: 463-76. |
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| 2. |
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Gaull, G.E. 1989. Taurine in
paediatric nutrition: review and update. Paediatrics.
83(3): 433-42. |
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| 3. |
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Lima ,L., Obregon, F., Cubillos, S., Fazzino,
F. & Jaimes, I. 2001. Taurine as a micronutrient in development
and regeneration of central nervous system. Nutr Neurosci.
4(6): 439-43. |
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| 4. |
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Marchesi, G.F. , Quarttrini, A., Scarpino,
O. & Dellantonio, R. 1975. Therapeutic effects of taurine
in epilepsy: a clinical and polyphysiographic study. Riv
Patol Nerv Ment. 96(3): 166-84. |
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| 5. |
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Militante, J.D, Lombardini, J.B. 2002. Taurine:
evidence of physiological function in the retina. Nutr
Neurosci. 5(2):75-90 |
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| 6. |
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Taurine in development. J Nutr. 118(10):1169-76.1988.
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| 7. |
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Taurine: retinal function. Brain Res Rev.
16(2): 151-69. 1991. |
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| 8. |
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Uauy, R. 2002. Clinical studies with LCPUFA:
what have they taught us? Instituto de Nutricion y Technologia
de los Alimentos (INTA) University of Chile. Medical Tribune.
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