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EFFICACY STUDIES/ SCIENTIFIC ARTICLES
 

Rationale of Iron Dosage and Formulations in Under Three Children

 

National Family Health Survey (NFHS)-2 data shows that 74 percent children age 6-35 months are anaemic. In Delhi, 64% children aged 9-36 months in an urban slum ICDS project were found anaemic, 44% being in moderate to severe category. Many studies from various centers of rural and urban Indian over last decade have shown such high prevalence. Associations between haemoglobin (Hb) concentration and psychomotor performance have been demonstrated at all stages of life. An Expert Consultation concluded that anaemia impairs the mental and motor development, and the behaviour of infants. There is also apprehension that developmental deficits that occur due to iron deficiency in infancy may be irreversible. Thus prevention of IDA in infants and growing children is an urgent need for improving the quality of life of our children.

Source: Allen, L.H. 2002. Rationale of Iron Dosage and Formulations in Under Three Children. Department of Paediatrics, Maulana Azad Medical College & Lok Nayak Hospital, New Delhi.

 

Early Childhood Anaemia And Mild Or Moderate Mental Retardation.

 

Previous studies questioned the link between early childhood anaemia and detrimental child development. A population-based study was conducted to examine the association between early childhood anaemia ad mild or moderate metal retardation at 10 years of age. Logistic regression showed an increased likelihood of mild or moderate mental retardation associated with anaemia, independent of birth weight, maternal education, sex, race-ethnicity, the motherĄ¯s age, or the childĄ¯s age at entry into the WIC (Special Supplemental Program for Women, Infants and Children). These findings support the proposition that efforts to prevent mild and moderate mental retardation should include providing children with adequate nutrition during early childhood.

Source: Hurtado, E.K., Claussen, A.H. & Scott, K.G. 1999. Early childhood anaemia and mild or moderate mental retardation. Am J Clin Nutr. 69: 115-9.

 
 
Iron Deficiency And Cognitive Achievement Among School-aged Children And Adolescents In The United States.
 

Iron deficiency anaemia in infants can cause developmental problems. However, the relationship between iron status and cognitive achievement in older children is less clear. To investigate the relationship between iron deficiency and cognitive test score among a nationally representative sample of school-aged children and adolescents. Among the 5398 children in the sample, 3% were iron-deficient. The prevalence of iron deficiency was highest among adolescent girls (8.7%). Average math scores were lower for children with iron deficiency with and without anaemia, compared with children with iron deficiency had greater than twice the risk of scoring below average in math than did children with normal iron status (odds ratio: 2.3; 95% confidence interval 1.1-4.4). This elevated risk was present even for iron-deficient children without anaemia (odds ratio: 2.4; 95% confidence interval: 1.1-5.2). We demonstrated lower standardised math scores among iron-deficient school-aged children and adolescents, including those with iron deficiency without anaemia. Screening for iron deficiency without anaemia may be warranted for children at risk.

Source: Halterman, JS, Kaczorowski, JM, Aligne, CA, Auinger, P and Szilagyi, PG. 2001. Iron deficiency and cognitive achievement among school-aged children and adolescents in the United States. Pediatrics. 107 (6): 1381-6.