| |
|
|
 |
EFFICACY STUDIES/ SCIENTIFIC ARTICLES |
|
|
|
| |
|
Relation of Serum Ascorbic Acid to Helicobacter pylori
Serology in US Adults: The Third National Health and Nutrition
Examination Survey |
| |
| Purpose: |
To examine
the relation between serum ascorbic acid and Helicobacter
pylori serology from a probability sample of US adults.
|
| |
Results: |
A total
of 2,189 adults (32%) had a positive serology for H. pylori,
and, of these, 1,175 (54%) were positive for the CagA antigen.
Among whites, a 0.50 mg/dL increase in serum ascorbic acid
level was associated with decreased seroprevalence of H.
pylori (Odds Ratio (OR) = 0.89, 95% confidence interval
(CI) CI 0.82–0.96, p < 0.01). In analyses
that controlled for seroprevalence of H. pylori,
a 0.50 mg/dL increase in serum ascorbic acid level among whites
was independently associated with a decreased seroprevalence
of the pathogenic cagA-positive strain of H.
pylori (OR = 0.31, 95% CI 0.12–0.79, p
< 0.05). Serum ascorbic acid levels were not significantly
associated with H. pylori serology among non-whites
(all p > 0.05). |
| |
| Conclusions: |
Higher serum
levels of ascorbic acid were associated with a decreased seroprevalence
of H. pylori and of the pathogenic cagA-positive
strain of H. pylori among whites. If these associations
are related causally and are not the result of residual confounding
by factors such as socioeconomic status, ascorbic acid may
affect the risk of H. pylori infection and in turn,
the risk for peptic ulcer disease and gastric cancer among
white Americans. |
| |
References: |
| 1. |
|
Simon, JA, Hudes,
ES, and Perez-Perez, GI. 2003. Relation of Serum Ascorbic
Acid to Helicobacter pylori Serology in US Adults:
the Third National Health and Nutrition Examination Survey
. Journal of the American College of Nutrition, 22(4):
283-289. |
|
| |
|
|
